In week 1, against the Atlanta Falcons, Smith scored his first career touchdown on his very first catch in the NFL. In Week 3, against the Washington Commanders, Smith had eight catches for a career-high 169 yards and a touchdown in the 24–8 win. Smith had five games going over the 100-yard mark in the 2022 season. Smith finished his second season catching 95 passes for 1,196 yards and seven touchdowns.